Besides the scientific gain of information, genomic breakpoint sequences of these patients were used to monitor minimal residual disease (MRD).
This study provides a comprehensive analysis of the KMT2A recombinome in acute leukemia patients. The seven most frequent TPGs and PTDs account for more than 90% of all recombinations of the KMT2A, 37 occur recurrently and 63 were identified so far only once. Further 16 rearrangements were out-of-frame fusions, 18 patients had no partner gene fused to 5’- KMT2A, two patients had a 5’- KMT2A deletion, and one ETV6::RUNX1 patient had an KMT2A insertion at the breakpoint. Including the published data from the literature, a total of 107 in-frame KMT2A gene fusions have been identified so far. Genomic breakpoints within the KMT2A gene and the involved translocation partner genes (TPGs) and KMT2A-partial tandem duplications (PTDs) were determined. Here, we present the data obtained from 3401 acute leukemia patients that have been analyzed between 20. Marschalek ORCID: /0000-0003-4870-3445 1Ĭhromosomal rearrangements of the human KMT2A/MLL gene are associated with de novo as well as therapy-induced infant, pediatric, and adult acute leukemias. If you want to build more powerful and flexible apps for your business, then FileMaker Pro Advanced is for you.ACUTE LYMPHOBLASTIC LEUKEMIA The KMT2A recombinome of acute leukemias in 2023 Plus, get robust analysis capabilities, powerful diagnostic tools, and much more. Get features to design and develop custom apps faster and easier. FileMaker Pro 15 Advanced 15.0.1.119 Multilingual (x86/圆4)įileMaker Pro Advanced includes all of the features of FileMaker Pro plus a set of advanced development and customization tools.
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